Horizontal bars in BCD represent the mean of the points shown. generated by somatic hypermutation (SHM). This process occurs in germinal centers (GCs), transient structures formed during T cellCdependent immune responses that enable the preferential survival of B cells producing higher affinity antibodies. Ultimately, this competitive selection process preserves GC B cells with improved antigen … Continue reading Horizontal bars in BCD represent the mean of the points shown